Reduced HDL function in children and young adults with type 1 diabetes

Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum levels of HDL cholesterol. The objective of this study was to evaluate HDL function in T1D pa...

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Bibliographic Details
Published in:Cardiovascular diabetology 2017-07, Vol.16 (1), p.85-85, Article 85
Main Authors: Heier, Martin, Borja, Mark S, Brunborg, Cathrine, Seljeflot, Ingebjørg, Margeirsdottir, Hanna Dis, Hanssen, Kristian F, Dahl-Jørgensen, Knut, Oda, Michael N
Format: Article
Language:English
Subjects:
Adolescent
Apolipoprotein A
Apolipoprotein A-I
Apolipoprotein A-I - blood
Arteriosclerosis
Atherosclerosis
Atherosclerosis - blood
Biological Transport - physiology
Cardiovascular disease
Cardiovascular diseases
Child
Children
Cholesterol
Cholesterol, HDL - blood
Diabetes mellitus
Diabetes Mellitus, Type 1 - metabolism
Female
HDL function
HDL-apoA-I exchange
Health risk assessment
Health risks
High density lipoprotein
Humans
Lipoproteins, HDL - blood
Low density lipoprotein
Male
Mortality
Original Investigation
Serum levels
Type 1 diabetes
Young adults
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Summary:Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum levels of HDL cholesterol. The objective of this study was to evaluate HDL function in T1D patients shortly after disease onset compared with healthy control subjects. Participants in the atherosclerosis and childhood diabetes study were examined at baseline and after 5 years. At baseline, the cohort included 293 T1D patients with a mean age of 13.7 years and mean HbA1c of 8.4%, along with 111 healthy control subjects. Their HDL function, quantified by HDL-apoA-I exchange (HAE), was assessed at both time points. HAE is a measure of HDL's dynamic property, specifically its ability to release lipid-poor apolipoprotein A-I (apoA-I), an essential step in reverse cholesterol transport. The HAE-apoA-I ratio, reflecting the HDL function per concentration unit apoA-I, was significantly lower in the diabetes group both at baseline, 0.33 (SD = 0.06) versus 0.36 (SD = 0.06) %HAE/mg/dL, p 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-017-0570-2