Retinal neurodegeneration in different risk phenotypes of diabetic retinal disease

Diabetic retinopathy (DR) has been considered a microvascular disease, but it has become evident that neurodegeneration also plays a key role in this complex pathology. Indeed, this complexity is reflected in its progression which occurs at different rates in different type 2 diabetic (T2D) individu...

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Bibliographic Details
Published in:Frontiers in neuroscience 2021-12, Vol.15, p.1-9
Main Authors: Madeira, Maria H., Marques, Inês P., Ferreira, Sónia, Tavares, Diana, Santos, Torcato, B M Santos, Ana Rita, Figueira, João, Lobo, Conceição, Cunha-Vaz, José
Format: Article
Language:English
Subjects:
Automation
Classification
Color vision
Diabetes
Diabetes mellitus
Diabetic retinopathy
Edema
Genotype & phenotype
Hemoglobin
Microvasculature
Neurodegeneration
Neuroscience
Personalized medicine
Phenotypes
Photography
Precision medicine
Progression
Retina
Retinopathy
Risk phenotypes
Thinning
Tomography
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Summary:Diabetic retinopathy (DR) has been considered a microvascular disease, but it has become evident that neurodegeneration also plays a key role in this complex pathology. Indeed, this complexity is reflected in its progression which occurs at different rates in different type 2 diabetic (T2D) individuals. Based on this concept, our group has identified three DR progression phenotypes that might reflect the interindividual differences: phenotype A, characterized by low microaneurysm turnover (MAT
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2021.800004