Cervical neoplastic lesions in relation to CD4 T‐lymphocyte counts and antiretroviral therapy among women with clinical stage 1 HIV in Yunnan, China

China lacks data demonstrating associations of cervical neoplastic lesions with CD4 T‐lymphocyte (CD4 cell) counts and antiretroviral therapy (ART) among HIV‐infected women, suggesting relevant investigations are needed. A total of 545 HIV‐infected women were enrolled in Yunnan, China, between 2011...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2020-06, Vol.36 (6), p.450-459
Main Authors: Zhang, Dong‐Yu, Chen, Wen, Zhang, Hong‐Yun, Lv, Song‐Qin, Lu, Xiao‐Ning, Tao, Yan‐Ping, Zhang, Mi, Liu, Jia‐Fa, Yang, Min, Qiao, You‐Lin, Braithwaite, Dejana
Format: Article
Language:English
Subjects:
Antiretroviral drugs
antiretroviral therapy
CD4 T‐lymphocyte
Cervical cancer
epidemiology
HIV
Human immunodeficiency virus
Lymphocytes
Medical records
Studies
Womens health
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Summary:China lacks data demonstrating associations of cervical neoplastic lesions with CD4 T‐lymphocyte (CD4 cell) counts and antiretroviral therapy (ART) among HIV‐infected women, suggesting relevant investigations are needed. A total of 545 HIV‐infected women were enrolled in Yunnan, China, between 2011 and 2013. CD4 cell counts and ART were measured via medical records and cervical neoplastic lesions were measured by professional pathologists. Multivariable logistic models, which treated cervical intraepithelial neoplasia (CIN) 1+ and CIN2+ as outcomes, calculated adjusted odds ratio (aOR) of CD4 cell counts and ART. Subgroup analysis treating CIN1+ as the outcome was conducted by HIV infection duration (
ISSN:1607-551X
2410-8650
DOI:10.1002/kjm2.12175