A murine model of xenotransplantation of human glioblastoma with imunosupression by orogastric cyclosporin

Several animal experimental models have been used in the study of malignant gliomas. The objective of the study was to test the efficacy of a simple, reproducible and low cost animal model, using human cells of glioblastoma multiforme (GBM) xenotransplantated in subcutaneous tissue of Wistar rats, i...

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Published in:Arquivos de neuro-psiquiatria 2011-02, Vol.69 (1), p.112-117
Main Authors: Cunha, Alexandre M., Nascimento, Fernanda S., Amaral, Jane C.O.F., Konig, Sandra, Takiya, Crhistina M., M. Neto, Vivaldo, Rocha, Eduardo, Souza, Jorge P.B.M.
Format: Article
Language:English
Subjects:
ciclosporina
glioblastoma
modelo animal
NEUROSCIENCES
PSYCHIATRY
ratos Wistar
xenotransplante
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Summary:Several animal experimental models have been used in the study of malignant gliomas. The objective of the study was to test the efficacy of a simple, reproducible and low cost animal model, using human cells of glioblastoma multiforme (GBM) xenotransplantated in subcutaneous tissue of Wistar rats, immunosuppressed with cyclosporin given by orogastric administration, controlled by nonimunosuppressed rats. The animals were sacrificed at weekly intervals and we have observed gradual growth of tumor in the immunosuppressed group. The average tumor volume throughout the experiment was 4.38 cm³ in the immunosuppressed group, and 0.27 cm³ in the control one (p
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/S0004-282X2011000100021