Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction

Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv....

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Bibliographic Details
Published in:Journal of Biological Research 2011-01, Vol.84 (1), p.122
Main Authors: Palmieri, D., Barisione, C., Pane, C, Spinella, G., Garibaldi, S., Ghigliotti, G., Brunelli, C., Fulcheri, E., Palombo, D.
Format: Article
Language:English
Subjects:
Andominal aortic aneurysm, Monocytes, MMPs, TNF-α
Aneurysms
Antioxidants
Aortic aneurysms
Elastase
Gelatinase B
Immune response
Inflammation
L-selectin
Monocytes
Resveratrol
Serum levels
Tumor necrosis factor-α
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Summary:Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.
ISSN:1826-8838
2284-0230
DOI:10.4081/jbr.2011.4638