Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA. We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA. We have also de...

Full description

Saved in:
Bibliographic Details
Published in:Stem cells international 2017-01, Vol.2017 (2017), p.1-11
Main Authors: Wang, Jinsheng, Pan, Lulu, Li, Lei, Ji, Kangting, Wang, Jie, Tao, Lu-yuan, Huang, Kai-yu, Wu, Shao-ze, Fang, Aili, Xue, Yang-jing, Wang, Jiao-ni, Zhou, Yingying, Shen, Yegen
Format: Article
Language:English
Subjects:
Abdomen
Abdominal aneurysm
Aneurysms
Angiotensin
Angiotensin II
Aortic aneurysms
Apoptosis
Atherosclerosis
Benzopyrene
Care and treatment
Cascade chemical reactions
Cell activation
Cell growth
Cells (biology)
Coronary vessels
Cytokines
Development and progression
DNA microarrays
Gene expression
Genetic aspects
Genomes
Health aspects
Hospitals
Macrophages
Messenger RNA
Ribonucleic acid
RNA
Smoking
Stem cells
Triglycerides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA. We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA. We have also demonstrated that macrophage activation plays a key role in Bap-induced AAA, but the mechanism is unknown. Here, we used a mouse lncRNA array to investigate the expression signatures of lncRNAs and mRNAs in Bap-activated macrophage. A total of 457 lncRNAs and 219 mRNAs were found to be differentially expressed. The function of differential mRNAs was determined by pathway and Gene Ontology analysis. Eight pathways associated with inflammation were upregulated, and seven pathways including cell apoptosis were downregulated. It was worth noting that AGE-RAGE pathway, which was involved in Bap-induced EPC dysfunction, was significantly upregulated in Bap-activated macrophage and may contribute to AAA formation. Thus, lncRNAs may exert a key role in activated macrophages and intervene the core lncRNAs and may inhibit the occurrence of a series of cascade reactions in the macrophages, which may provide potential targets for AAA caused by smoking.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2017/9495739