Evaluation of urinary L-FABP as an early marker for diabetic nephropathy in type 2 diabetic patients

Albuminuria is the standard biomarker for the diagnosis of diabetic nephropathy (DN). However, some patients with persistent microalbuminuria still progress to chronic kidney disease, raising the question of finding a better biomarker. This study aimed to evaluate the correlation of urinary liver-ty...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical biochemistry 2020-01, Vol.39 (2), p.224-230
Main Authors: Thi, Thuy Ngan Duong, Gia, Binh Nguyen, Thi, Huong Lan Le, Thi, Thu Nguyen Cuc, Thanh, Huong Phung
Format: Article
Language:English
Subjects:
albuminuria
diabetic nephropathy
Original Paper
type 2 diabetes
urinary l-fabp
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Albuminuria is the standard biomarker for the diagnosis of diabetic nephropathy (DN). However, some patients with persistent microalbuminuria still progress to chronic kidney disease, raising the question of finding a better biomarker. This study aimed to evaluate the correlation of urinary liver-type fatty acid-binding protein (L-FABP) levels with renal function and to compare the role of urinary albumin-to-creatinine ratio (ACR) with urinary L-FABP in early detection of DN in type 2 diabetic patients. The cross-sectional study was done on 106 type 2 diabetic patients and 30 non-diabetic people. L-FABP was measured with the Latex enhanced immunoturbidimetric technique. There was a strong and negative correlation between the urine L-FABP levels and eGFR (r = -0.606, p
ISSN:1452-8258
1452-8266
1452-8266
DOI:10.2478/jomb-2019-0037