Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, it provides an overview of the models that have been used as representations of...

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Bibliographic Details
Published in:Frontiers in physiology 2014-12, Vol.5, p.464-464
Main Authors: DeCant, Brian T, Principe, Daniel R, Guerra, Carmen, Pasca di Magliano, Marina, Grippo, Paul J
Format: Article
Language:English
Subjects:
Conditional and Inducible Systems
Cre Lox Technology
Engineering Mouse Models
Frt Flp Technology
Pancreatic Cancer
Physiology
TET inducible Systems
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Summary:The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, it provides an overview of the models that have been used as representations of both the neoplastic and carcinoma phenotypes. Second, it presents new modeling schemes that ultimately will serve to more faithfully capture the temporal and spatial progression of the human disease, providing platforms for improved understanding of the role of non-epithelial compartments in disease etiology as well as evaluating therapeutic approaches.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2014.00464