Linear and Non-Linear Middle Infrared Spectra of Penicillin G in the CO Stretching Mode Region

In this work we report the linear and non-linear IR spectral response characterization of the CO bonds of PenicillinG sodium salt in D2O and in DMSO−d6 solutions. In order to better characterize the spectral IR features in the CO stretching region, broadband middle infrared pump-probe spectra are re...

Full description

Saved in:
Bibliographic Details
Published in:Symmetry (Basel) 2021-01, Vol.13 (1), p.106
Main Authors: Ragnoni, Elena, Catalini, Sara, Becucci, Maurizio, Lapini, Andrea, Foggi, Paolo
Format: Article
Language:English
Subjects:
Amides
Anharmonicity
Antibiotics
Broadband
Carbon monoxide
CO stretching
Couplings
Experiments
Hydrogen bonds
infrared
Infrared spectra
Infrared spectroscopy
Lasers
non-linear infrared
Oscillators
Penicillin
Peptides
Sodium salts
Spectral sensitivity
Spectrum analysis
Stretching
vibrational dynamics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work we report the linear and non-linear IR spectral response characterization of the CO bonds of PenicillinG sodium salt in D2O and in DMSO−d6 solutions. In order to better characterize the spectral IR features in the CO stretching region, broadband middle infrared pump-probe spectra are recorded. The role of hydrogen bonds in determining the inhomogeneous broadening and in tuning anharmonicity of the different types of oscillators is exploited. Narrow band pump experiments, at the three central frequencies of β−lactam, amide and carboxylate CO stretching modes, identify the couplings between the different types of CO oscillators opening the possibility to gather structural dynamic information. Our results show that the strongest coupling is between the β−lactam and the carboxylate CO vibrational modes.
ISSN:2073-8994
2073-8994
DOI:10.3390/sym13010106