Spinal or Intravenous Dexmedetomidine for Spinal Anesthesia with Chloroprocaine in Ambulatory Knee Arthroscopies: A Double-Blind Randomized Trial

• Published in: Local and regional anesthesia 2021-11, Vol.14, p.153-160
• Main Authors: Breebaart, Margaretha B, Saerens, Lies, Branders, Jordi, Casaer, Sari, Sermeus, Luc, Van Houwe, Patrick
• Format: Article
• Language: English
• Subjects: ambulatory surgery; Anesthesia; Arthroscopy; Bladder; bladder function; Cardiac arrhythmia; Chloroprocaine; Clinical Trial Report; Clinical trials; Dexmedetomidine; Double-blind studies; Endoscopic surgery; Ethical aspects; General anesthesia; Hypotension; Joints; knee arthroscopy; Pain; Patients; spinal anesthesia; Sufentanil; Surgery; Surgical clinics
• ISSN: 1178-7112; 1178-7112
• DOI: 10.2147/LRA.S324876

Chloroprocaine provides spinal anesthesia for day-case surgery lasting up to 40 minutes. Intravenous and spinal dexmedetomidine can prolong spinal anesthesia, but no data are available for the combination with chloroprocaine. This double-blind randomized controlled trial compares chloroprocaine with spinal or intravenous dexmedetomidine regarding block characteristics, micturition, and discharge times. After ethical approval and informed consent, 135 patients scheduled for knee arthroscopy were randomized to receive either 40mg spinal chloroprocaine (Chloro-group), 40mg chloroprocaine with 5 mcg spinal dexmedetomidine (Spinal Dex-group) or 40mg chloroprocaine with 0.5 mcg/kg IV dexmedetomidine (IV DEXgroup). Block characteristics, hemodynamic variables and the use of analgesics were registered. Voiding and discharge times were noted. A scoring system was used for micturition problems and sedation. Transient neurological symptoms (TNS) and other late side effects were evaluated after one week. Demographic data were similar between groups. Block onset times and intensity of motor block were comparable between groups. The time to L2 and Bromage 1 regression was prolonged in the SpinalDEx-group by approximately 30 minutes compared to the other groups (p < 0.01). First voiding as well as discharge from the hospital was prolonged in the Spinal Dex-group by approximately 40 minutes p < 0.01. There was no significant difference between groups regarding treatment of hypotension, sedation, micturition problems or the use of postoperative analgesics (P > 0.8). One patient experienced TNS. Intrathecal but not intravenous (0.5 mcg/kg) dexmedetomidine can prolong chloroprocaine (40mg) spinal anesthesia when surgery is expected to last over 40 minutes. Despite a similar incidence of adverse effects, this also led to a postponed hospital discharge time.