The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection

T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF-β, IL6, IL21, and IL23). Recent studies involving exp...

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Bibliographic Details
Published in:Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-13
Main Authors: Qi, Xiaoming, Li, Zhenhao, Gao, Xiaoling, Wu, Yu, Jia, Yanjuan, Guo, Rui, Wei, Zhenhong, Jia, Jing, Xu, Hui, Wei, Chaojun, Li, Yonghong, Li, Yuanting
Format: Article
Language:English
Subjects:
Antigens
Arthritis
Bacteria
Bacterial infections
BCG
BCG vaccines
Bone morphogenetic proteins
Chlamydia
Cytokines
Dendritic cells
Health aspects
Helper cells
Immunology
Immunoregulation
Infections
Infectious diseases
Interleukin 1
Interleukin 17
Interleukin 21
Interleukin 23
Interleukin 6
Intracellular
Lymphocytes
Lymphocytes T
Pathogens
Review
Rodents
Salmonella
Stat3 protein
T cells
Transcription
Transforming growth factors
Tuberculosis
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Summary:T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF-β, IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17 plays a crucial role in host defense against a variety of pathogens, including bacteria and viruses. The underlying mechanisms by which Th17 performs include dendritic cell (DC) regulation, neutrophil recruitment, Th1 modulation, and T regulatory cell (Treg) balance. In recent years, researchers have generated an accumulating wealth of evidence on the role of Th17/IL17 in protective immunity to intracellular bacterial pathogens, such as Mycobacterium tuberculosis and Chlamydia trachomatis, which are one of the most important pathogens that inflict significant socioeconomic burden across the globe. In this article, we reviewed the current literature on the functions and mechanisms by which Th17/IL17 responds to intracellular bacterial infections. A better understanding of Th17/IL17 immunity to pathogens would be crucial for developing effective prophylactics and therapeutics.
ISSN:0962-9351
1466-1861
DOI:10.1155/2018/6587296