Cis-(3-benzyloxy-1,1-cyclobutanedicarboxylato κ2O,O′)bis(1-methyl-1H-pyrazole)platinum(II)

A huge variety of types of cancer makes it necessary to search for new effective drugs with a defined molecular target. Modification of substituents in ligands based on 3-hydroxy-1,1-cyclobutanedicarboxylic acid are one of the effective directions to design a better version of carboplatin. In the pr...

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Bibliographic Details
Published in:MolBank 2023-03, Vol.2023 (1), p.M1564
Main Authors: Pavlova, Anna S., Buslaev, Daniil A., Borisova, Nataliya E., Temnov, Victor V., Nazarov, Alexey A., Podrugina, Tatyana A.
Format: Article
Language:English
Subjects:
1-methyl-1H-pyrazole ligand
3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid
antiproliferative activity
Cancer
Dicarboxylic acids
Fibroblasts
Ligands
platinum (II) complexes
Pyrazole
Spectrum analysis
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Summary:A huge variety of types of cancer makes it necessary to search for new effective drugs with a defined molecular target. Modification of substituents in ligands based on 3-hydroxy-1,1-cyclobutanedicarboxylic acid are one of the effective directions to design a better version of carboplatin. In the present study, we combined in one molecule a derivative of 3-hydroxycyclobutane-1,1-dicarboxylic acid and N-methylpyrazole as a carrier ligand. The antiproliferative of the novel complex Pt(II) was established for cell lines HCT116, MCF7, A549, and WI38 by means of a standard MTT colorimetric assay.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1564