Discovery of Novel Hybrid-Type Strigolactone Mimics Derived from Cinnamic Amide

Strigolactones (SLs) are a class of plant hormones and rhizosphere communication signals of great interest. They perform diverse biological functions including the stimulation of parasitic seed germination and phytohormonal activity. However, their practical use is limited by their low abundance and...

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Published in:International journal of molecular sciences 2023-06, Vol.24 (12), p.9967
Main Authors: Wang, Chunying, Guo, Bingbo, Yang, Zhaokai, Du, Lin, Yu, Chunxin, Zhou, Yuyi, Zhao, Hanqing, Wang, Ye, Duan, Liusheng
Format: Article
Language:English
Subjects:
Arabidopsis
Arabidopsis - metabolism
Arabidopsis thaliana
Biological activity
cinnamic amide
Elongation
Germination
Gibberellins
Growth regulators
Hormones
Hydrocarbons
Lactones - chemistry
lateral root formation
Molecular docking
Molecular Docking Simulation
Physiological aspects
Plant growth
Plant Growth Regulators - metabolism
Plant physiology
Rhizosphere
root growth
root hair elongation
Root hairs
Seed germination
Seeds
strigolactones
Weeds
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Summary:Strigolactones (SLs) are a class of plant hormones and rhizosphere communication signals of great interest. They perform diverse biological functions including the stimulation of parasitic seed germination and phytohormonal activity. However, their practical use is limited by their low abundance and complex structure, which requires simpler SL analogues and mimics with maintained biological function. Here, new, hybrid-type SL mimics were designed, derived from Cinnamic amide, a new potential plant growth regulator with good germination and rooting-promoting activities. Bioassay results indicated that compound not only displayed good germination activity against the parasitic weed with an EC value of 2.36 × 10 M, but also exhibited significant inhibitory activity against root growth and lateral root formation, as well as promoting root hair elongation, similar to the action of GR24. Further morphological experiments on mutants revealed that possessed SL-like physiological functions. Furthermore, molecular docking studies indicated that the binding mode of was similar to that of GR24 in the active site of OsD14. This work provides valuable clues for the discovery of novel SL mimics.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24129967