A Rare Case of Renal Thrombotic Microangiopathy and Focal Segmental Glomerulosclerosis Secondary to Plasma Cell Leukemia

Plasma cell dyscrasias are a subset of hematological malignancies involving the production of monoclonal immunoglobulins. This spectrum of disorders includes asymptomatic conditions such as monoclonal gammopathy of unknown significance as well as extremely aggressive malignancies such as plasma cell...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in hematology 2023-02, Vol.2023, p.7803704-4
Main Authors: Komisarof, Justin, Forman, Jessica, Goldman, Bruce, Syposs, Chauncey, Passero, Frank, Garbade, Ellie
Format: Article
Language:English
Subjects:
Anemia
Biopsy
Bone marrow
Carfilzomib
Case Report
Case reports
Chemotherapy
Creatinine
Hospitals
Hypertension
Kidney diseases
Leukemia
Multiple myeloma
Pathophysiology
Plasma
Proteins
Thrombocytopenia
Urinalysis
Working groups
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasma cell dyscrasias are a subset of hematological malignancies involving the production of monoclonal immunoglobulins. This spectrum of disorders includes asymptomatic conditions such as monoclonal gammopathy of unknown significance as well as extremely aggressive malignancies such as plasma cell leukemia. Monoclonal gammopathies are occasionally associated with renal failure, which can occur via many pathophysiological processes. The most common of these is light chain cast nephropathy, but many rare renal complications exist, including thrombotic microangiopathy (TMA) and focal segmental glomerulosclerosis (FSGS). Here, we report a patient with new renal failure with features of TMA and FSGS on biopsy and found to be secondary to plasma cell leukemia.
ISSN:2090-6560
2090-6579
DOI:10.1155/2023/7803704