Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1 H and 13 C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P2 1 /n...

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Bibliographic Details
Published in:Central European journal of chemistry 2010-06, Vol.8 (3), p.550-558
Main Authors: Saeed, Sohail, Rashid, Naghmana, Jones, Peter G., Hussain, Rizwan, Bhatti, Moazzam Hussain
Format: Article
Language:English
Subjects:
Antifungal activity
Biochemistry
Biological and Medical Physics
Biophysics
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Geochemistry
Mass fragmentation
Research Article
Thiazole
Thiourea derivatives
X-ray structure determination
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Summary:Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1 H and 13 C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P2 1 /n with unit cell dimensions a = 11.7752(6) Å, b= 3.8677(2) Å, c= 27.4126(13) Å and β = 92.734(5) Å. There is a strong intramolecular hydrogen bond of the type N-H⋯O, with H⋯O distance of 2.5869(19) Å. The mass fragmentation pattern has also been discussed. The antifungal activity of the synthesized compounds was studied by broth micro-dilution method and poisoned food technique. The compounds 1b and 1c possessed a broad spectrum of antifungal activity.
ISSN:1895-1066
2391-5420
1644-3624
2391-5420
DOI:10.2478/s11532-010-0014-2