The Association Between the rs2200733 SNP and Atrial Fibrillation Among Arabs: A Study from Jordan

• Published in: Biologics 2024-01, Vol.18, p.389-395
• Main Authors: Al-Kasasbeh, Abdullah H, Khabour, Omar F, Almomani, Rowida, Ababneh, Muhannad, Ibdah, Rashid, Jarrah, Mohamad Ismail, Rawashdeh, Sukaina I, Seif, Abdelsamea Mohammed
• Format: Article
• Language: English
• Subjects: Alleles; arabs; atrial fibrillation; Body mass index; Cardiac arrhythmia; Cardiology; Cardiovascular disease; Congenital diseases; Diabetes; Diabetes mellitus; Environmental factors; Enzymes; Family medical history; Fibrillation; Gene frequency; Gene polymorphism; Genotype & phenotype; Heart failure; Hispanic Americans; Homeobox; jordan; Mutants; Original Research; pitx2; Polymerase chain reaction; Polymorphism; Population; Population genetics; Population studies; Restriction fragment length polymorphism; rs2200733; Single-nucleotide polymorphism; Sleep apnea; Stroke; Thyroid gland
• ISSN: 1177-5475; 1177-5491; 1177-5491
• DOI: 10.2147/BTT.S490891

Atrial fibrillation (AFib) is a common disorder featured by an irregular and fast heartbeat. The etiology of AFib is complex and involves genetic and environmental factors. The rs2200733 single nucleotide polymorphism (SNP) is located in close proximity to the promoter of paired-like homeodomain transcription factor 2 (PITX2) which plays a role in heart development. In this study, the association between the rs2200733 SNP and AFib was examined in the Jordanian population. The study included 450 subjects (274 controls and 176 patients with AFib). Patients were recruited from King Abdullah University Hospital based on the European Society of Cardiology criteria. The rs2200733 SNP was genotyped using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. The mutant T allele of the rs2200733 SNP was common in the studied population with a frequency of 19%. The T allele and CT/TT genotypes were prevalent among patients with AFib compared with the controls (P