Long non-coding RNA MIAT in development and disease: a new player in an old game

Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. Myocardial infarction associated transcript (MIAT), which was recently found to...

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Bibliographic Details
Published in:Journal of biomedical science 2018-03, Vol.25 (1), p.23-23, Article 23
Main Authors: Sun, Cheng, Huang, Lining, Li, Zhenglong, Leng, Kaiming, Xu, Yi, Jiang, Xingming, Cui, Yunfu
Format: Article
Language:English
Subjects:
Biomarkers - metabolism
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Diseases
Gene expression
Genetic aspects
Health aspects
Heart attack
Humans
LncRNA
Long non-coding RNA
Methods
MIAT
Myocardial Infarction - genetics
Noncommunicable Diseases
Review
RNA sequencing
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
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Summary:Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA. This work summarize current evidence regarding the biological functions and underlying mechanisms of lncRNA MIAT during disease development. LncRNA MIAT likely represents a feasible cancer biomarker or therapeutic target.
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/s12929-018-0427-3