Microwave-Synthesized Platinum-Embedded Mesoporous Silica Nanoparticles as Dual-Modality Contrast Agents: Computed Tomography and Optical Imaging

Nanoparticle-based imaging contrast agents have drawn tremendous attention especially in multi-modality imaging. In this study, we developed mesoporous silica nanoparticles (MSNs) for use as dual-modality contrast agents for computed tomography (CT) and near-infrared (NIR) optical imaging (OI). A mi...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-03, Vol.20 (7), p.1560
Main Authors: Chu, Chia-Hui, Cheng, Shih-Hsun, Chen, Nai-Tzu, Liao, Wei-Neng, Lo, Leu-Wei
Format: Article
Language:English
Subjects:
Adsorption
Biocompatibility
Biodegradation
Catalase
Catalysis
Catalytic activity
Computed tomography
computed tomography (CT)
Contrast agents
Cytotoxicity
dual-modality contrast agents
Excretion
Iron oxides
Ligands
Magnetic resonance imaging
Medical imaging
Medical prognosis
mesoporous silica nanoparticles (MSNs)
microwave synthesis
naked platinum nanoparticles (nPtNPs)
Nanoparticles
NMR
Nuclear magnetic resonance
Organs
Peptides
Peroxidase
Platinum
Polyethylene glycol
Pore size
Protein adsorption
Quantum dots
Silica
Superoxide dismutase
Therapeutic applications
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Summary:Nanoparticle-based imaging contrast agents have drawn tremendous attention especially in multi-modality imaging. In this study, we developed mesoporous silica nanoparticles (MSNs) for use as dual-modality contrast agents for computed tomography (CT) and near-infrared (NIR) optical imaging (OI). A microwave synthesis for preparing naked platinum nanoparticles (nPtNPs) on MSNs (MSNs-Pt) was developed and characterized with physicochemical analysis and imaging systems. The high density of nPtNPs on the surface of the MSNs could greatly enhance the CT contrast. Inductively coupled plasma mass spectrometry (ICP-MS) revealed the MSNs-Pt compositions to be ~14% Pt by weight and TEM revealed an average particle diameter of ~50 nm and covered with ~3 nm diameter nPtNPs. To enhance the OI contrast, the NIR fluorescent dye Dy800 was conjugated to the MSNs-Pt nanochannels. The fluorescence spectra of MSNs-Pt-Dy800 were very similar to unconjugated Dy800. The CT imaging demonstrated that even modest degrees of Pt labeling could result in substantial X-ray attenuation. In vivo imaging of breast tumor-bearing mice treated with PEGylated MSNs-Pt-Dy800 (PEG-MSNs-Pt-Dy800) showed significantly improved contrasts in both fluorescence and CT imaging and the signal intensity within the tumor retained for 24 h post-injection.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20071560