Voxel-based morphometry reveals altered gray matter volume related to cognitive dysfunctioning in neovascular glaucoma patients

We used correlation analysis to examine whether changes in grey matter volume in patients correlated with clinical presentation. gray matter volume was markedly reduced in neovascular glaucoma patients than healthy controls in the following brain regions: left cingulum anterior/medial frontal gyrus;...

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Bibliographic Details
Published in:Journal of integrative neuroscience 2021-12, Vol.20 (4), p.839-846
Main Authors: Zhao, Hui, Shi, Yi-Dan, Liang, Rong-Bin, Ge, Qian-Ming, Pan, Yi-Cong, Zhang, Li-Juan, Shu, Hui-Ye, Li, Qiu-Yu, Shao, Yi
Format: Article
Language:English
Subjects:
Adult
Cerebral Cortex
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Female
fmri
Glaucoma, Neovascular - complications
Glaucoma, Neovascular - diagnostic imaging
Glaucoma, Neovascular - pathology
Glaucoma, Neovascular - physiopathology
Gray Matter - diagnostic imaging
Gray Matter - pathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
neovascular glaucoma
visual pathway
voxel-based morphometry
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Summary:We used correlation analysis to examine whether changes in grey matter volume in patients correlated with clinical presentation. gray matter volume was markedly reduced in neovascular glaucoma patients than healthy controls in the following brain regions: left cingulum anterior/medial frontal gyrus; left middle frontal gyrus, orbital part; left inferior frontal gyrus, orbital part; superior temporal gyrus/right frontal inferior orbital part. VBM directly suggests that neovascular glaucoma patients have changed in the volume of multiple brain regions. These changes exist in brain areas related to the visual pathway, as well as other brain areas which are not related to vision. The alteration of specific brain areas are closely related to clinical symptoms such as increased intraocular pressure and optic nerve atrophy in neovascular glaucoma patients. In conclusion, neovascular glaucoma may cause paralgesia, anxiety, and depression in patients.
ISSN:0219-6352
1757-448X
DOI:10.31083/j.jin2004086