Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus

This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. All infants were voluntarily chosen by their mothers and divided into bre...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.1819-1827
Main Authors: Zhou, Mingshu, Li, Li, Han, Lirong, Sun, Fangli, Yi, Nuo
Format: Article
Language:English
Subjects:
Antigens
Breast feeding
breast-feeding group
Breastfeeding & lactation
Disease susceptibility
formula-feeding group
Hepatitis B
Hepatitis B virus
Infants
Infections
Laboratories
Liver
mother-to-child transmission
Mothers
Newborn babies
Original Research
Pregnant women
Risk factors
Vaccines
Viral infections
Womens health
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Summary:This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. All infants were voluntarily chosen by their mothers and divided into breast-feeding group and formula-feeding group, which were divided into three subgroups, respectively: HBV-DNA negative (HBV-) group, low viral load (LVL) group and high viral load (HVL) group. HBV load in colostrum and mature milk were both significantly lower than in serum (P < 0.001). The positive rate of HBV-DNA in colostrum was positively correlated with HBV load in serum, significantly higher than that of the HBV-Group in colostrum in the LVL Group (P < 0.05), and the HVL Group was significantly higher than the LVL Group (P < 0.001). The analysis of risk factors of HBV infection in infants showed that breast-feeding and HBsAg positive in colostrum did not increase the risks of HBV infection of infants (P > 0.05). Breast-feeding is safe for infants with HBV-infected mothers who receive active immunization combined with passive immunization. As well, breast-feeding will neither increase the risks of HBV infection for infants nor weaken their immunity to HBV. However, breast-feeding shall be cautiously applied to pregnant women with high viral load.
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S289804