Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure

Critically ill patients with COVID continue to die at an alarming rate—a recent case series published in JAMA reported 88.1% mortality for patients requiring mechanical ventilation in a large health care system in New York [5]. At this time, in the absence of more specific labs, the clinician’s chal...

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Bibliographic Details
Published in:Critical care (London, England) England), 2020-05, Vol.24 (1), p.226-226, Article 226
Main Authors: Honore, Patrick M, Mugisha, Aude, Kugener, Luc, Redant, Sebastien, Attou, Rachid, Gallerani, Andrea, De Bels, David
Format: Article
Language:English
Subjects:
Adult respiratory distress syndrome
Betacoronavirus
Care and treatment
Coronavirus
Coronavirus Infections
Coronaviruses
COVID-19
Critical care
Health aspects
Humans
Investigations
Letter
Pandemics
Plasma
Plasma Exchange
Plasma exchange (Therapeutics)
Pneumonia, Viral
SARS-CoV-2
Sepsis
Septic shock
Shock, Septic
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Summary:Critically ill patients with COVID continue to die at an alarming rate—a recent case series published in JAMA reported 88.1% mortality for patients requiring mechanical ventilation in a large health care system in New York [5]. At this time, in the absence of more specific labs, the clinician’s challenge of evaluating patients and making the most appropriate treatment decisions must mainly be guided by the clinical parameters, as determined by currently available resources and evidence. Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-020-02943-1