Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder: a nationwide study with 20 years of follow-up

Background Patients with severe mental illness (SMI) have a reduced life expectancy of one to two decades as compared to the general population, with most years of life lost due to somatic diseases. Most previous studies on disorders constituting SMI, e.g. schizophrenia and bipolar disorder, have in...

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Bibliographic Details
Published in:International Journal of Bipolar Disorders 2019-03, Vol.7 (1), p.6-8, Article 6
Main Authors: Lomholt, Line Hosbond, Andersen, Diana Vincens, Sejrsgaard-Jacobsen, Christina, Øzdemir, Cagla Margit, Graff, Claus, Schjerning, Ole, Jensen, Svend Eggert, Straszek, Sune Puggard Vogt, Licht, Rasmus W., Grøntved, Simon, Nielsen, René Ernst
Format: Article
Language:English
Subjects:
Behavioral Therapy
Bipolar disorder
Clinical Psychology
Epidemiology
Health risk assessment
Medicine
Medicine & Public Health
Mortality
Neurology
Population
Psychiatry
Psychopharmacology
Psychotherapy
Schizophrenia
Studies
Trends
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Summary:Background Patients with severe mental illness (SMI) have a reduced life expectancy of one to two decades as compared to the general population, with most years of life lost due to somatic diseases. Most previous studies on disorders constituting SMI, e.g. schizophrenia and bipolar disorder, have investigated the disorders separately and hence not compared the disorders in terms of mortality rates relative to the background population. Methods A register-based cohort study including the entire Danish population comparing mortality rates relative to the background population, controlling for age and sex, i.e. standardized mortality ratios (SMRs) in patients diagnosed with schizophrenia with those in patients diagnosed with bipolar disorder, during the study period from 1995 to 2014. Results The SMR of patients with SMI was significantly higher than one for each calendar year in the study period with an overall SMR of 4.58, 95% CI (4.48–4.69) in patients diagnosed with schizophrenia (n = 38,500) and of 2.57 (95% CI 2.49–2.65) in patients diagnosed with bipolar disorder (n = 23,092). When investigating time trends in SMR for schizophrenia and for bipolar disorder, respectively, an increase in SMR over time was shown with a mean increase of 0.03 per year for schizophrenia and 0.02 for bipolar disorder (p 
ISSN:2194-7511
2194-7511
DOI:10.1186/s40345-018-0140-x