Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia

Pendrin (SLC26A4), a Cl /anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in othe...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2019-02, Vol.20 (3), p.731
Main Authors: Vanoni, Simone, Scantamburlo, Giada, Dossena, Silvia, Paulmichl, Markus, Nofziger, Charity
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
airway epithelium
Allergic rhinitis
Animal models
Asthma
Binding sites
CD4 antigen
Cell activation
Chemokines
Chronic infection
Chronic obstructive pulmonary disease
Cyclooxygenase-2
Cystic fibrosis
Cytokines
Disease
eosinophilic esophagitis
Esophageal diseases
esophageal epithelium
Esophagus
Gastrointestinal diseases
Gene expression
Gene regulation
Genes
Hearing loss
Helices
Hereditary diseases
Inflammation
Interleukin 13
Interleukin 17
Interleukin 4
Interleukin 6
Interleukin 8
interleukins
Kinases
Ligands
Monocyte chemoattractant protein 1
Muscles
pendrin
Phosphorylation
Proteins
Respiratory tract
Review
Rhinovirus
Smooth muscle
Splicing
Thyroid gland
Transcription
Transcription factors
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pendrin (SLC26A4), a Cl /anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in other tissues, such as airways and esophageal epithelia, where it is transcriptionally regulated by the inflammatory cytokines interleukin (IL)-4 and IL-13 through a signal transducer and activator of transcription 6 (STAT6)-mediated pathway. In the airway epithelium, increased pendrin expression during inflammatory diseases leads to imbalances in airway surface liquid thickness and mucin release, while, in the esophageal epithelium, dysregulated pendrin expression is supposed to impact the intracellular pH regulation system. In this review, we discuss some of the recent findings on interleukin-mediated transcriptional regulation of pendrin and how this dysregulation impacts airway and esophagus epithelial homeostasis during inflammatory diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20030731