Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers

The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the flu...

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Bibliographic Details
Published in:Nature communications 2024-04, Vol.15 (1), p.3381-9, Article 3381
Main Authors: Kim, Min Pyeong, Kayal, Swatilekha, Hwang, Chiwon, Bae, Jonghoon, Kim, Hyunseok, Hwang, Dong Gyu, Jeon, Min Ho, Seo, Jeong Kon, Ahn, Dowon, Lee, Wonjoo, Seo, Sangwon, Chun, Joong-Hyun, Yu, Youngchang, Hong, Sung You
Format: Article
Language:English
Subjects:
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Adhesives
Bisphenol A
Chemical synthesis
Chemistry
Copolymers
Fluorides
Homology
Humanities and Social Sciences
Iterative methods
Mass spectrometry
Mass spectroscopy
multidisciplinary
Polymerization
Polymers
Science
Science (multidisciplinary)
Shear tests
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Summary:The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion. The synthetic utility of this iterative ligation is demonstrated by preparing crosslinked network polymers as synthetic adhesive materials. The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. Here, the authors report a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-47567-z