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Metastases of soft tissue sarcoma to the liver: A Historical Cohort Study from a Hospital‐based Cancer Registry
Background Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type. Methods From a Hospital‐based Cancer Registry, 658 patients registered between...
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Published in: | Cancer medicine (Malden, MA) MA), 2020-09, Vol.9 (17), p.6159-6165 |
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Main Authors: | , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
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Online Access: | Get full text |
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Summary: | Background
Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type.
Methods
From a Hospital‐based Cancer Registry, 658 patients registered between 2007 and 2017 with soft tissue sarcomas were evaluated. The exclusion criteria were gastrointestinal stromal tumors, tumors of unknown origin, and follow‐up periods of less than 1 month. SPSS 25 was used for statistical analysis.
Results
The risk of hepatic metastasis was significantly higher in the retroperitoneum (HR, 5.981; 95% CI, 2.793‐12.808) and leiomyosarcoma (HR, 4.303; 95% CI, 1.782‐10.390). Multivariate analysis showed that the risk of hepatic metastasis as first distant metastasis was high in leiomyosarcoma (HR, 4.546; 95% CI, 2.275‐9.086) and retroperitoneal onset (HR, 4.588; 95% CI, 2.280‐9.231). The 2‐year survival rate after hepatic metastasis was 21.7%.
Conclusions
The onset of hepatic metastasis indicates a poor prognosis. However, hepatic metastasis from retroperitoneal sarcoma and leiomyosarcoma may be the first distant metastasis in some cases. For retroperitoneal sarcoma and leiomyosarcoma, additional screening for hepatic metastasis such as contrast CT should be considered during staging and follow‐up after treatment.
Following the analysis of 658 cases of soft tissue sarcomas excluding gastrointestinal stromal tumors registered in the Hospital‐based Cancer Registry from 2007 to 2017, we found that the percentage of retroperitoneal sarcomas and leiomyosarcomas causing hepatic metastasis was high at first visit, as the first distant metastasis, and throughout the entire course of the disease. For retroperitoneal sarcomas and leiomyosarcomas, additional screening for hepatic metastases should be considered during staging and postoperative follow‐up. |
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ISSN: | 2045-7634 2045-7634 |
DOI: | 10.1002/cam4.3304 |