Autophagy functions as an antiviral mechanism against geminiviruses in plants

Autophagy is an evolutionarily conserved process that recycles damaged or unwanted cellular components, and has been linked to plant immunity. However, how autophagy contributes to plant immunity is unknown. Here we reported that the plant autophagic machinery targets the virulence factor βC1 of (CL...

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Bibliographic Details
Published in:eLife 2017-02, Vol.6
Main Authors: Haxim, Yakupjan, Ismayil, Asigul, Jia, Qi, Wang, Yan, Zheng, Xiyin, Chen, Tianyuan, Qian, Lichao, Liu, Na, Wang, Yunjing, Han, Shaojie, Cheng, Jiaxuan, Qi, Yijun, Hong, Yiguo, Liu, Yule
Format: Article
Language:English
Subjects:
Antiviral agents
Antiviral drugs
antiviral immunity
Apoptosis
ATG8
Autophagy
Autophagy-Related Protein 8 Family - genetics
Autophagy-Related Protein 8 Family - metabolism
China
Cloning
Cotton
Deoxyribonucleic acid
Disease
Disease resistance
Disease susceptibility
DNA
DNA viruses
Geminiviridae - immunology
geminivirus
Gene silencing
Genomes
Health aspects
Immunoglobulins
Infections
Leaves
Life sciences
Nicotiana - genetics
Nicotiana - immunology
Nicotiana - virology
Pathogens
Phagocytosis
Plant Biology
Plant genetics
Plant immunity
Plant physiology
Plant viruses
plant-virus interaction
Plants (Organisms)
Proteins
Risk factors
Viral infections
Viral proteins
Virulence factors
Virus diseases
Viruses
Yellow leaf
βC1
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Summary:Autophagy is an evolutionarily conserved process that recycles damaged or unwanted cellular components, and has been linked to plant immunity. However, how autophagy contributes to plant immunity is unknown. Here we reported that the plant autophagic machinery targets the virulence factor βC1 of (CLCuMuV) for degradation through its interaction with the key autophagy protein ATG8. A V32A mutation in βC1 abolished its interaction with NbATG8f, and virus carrying βC1 showed increased symptoms and viral DNA accumulation in plants. Furthermore, silencing of autophagy-related genes and reduced plant resistance to the DNA viruses CLCuMuV, , and , whereas activating autophagy by silencing genes enhanced plant resistance to viral infection. Thus, autophagy represents a novel anti-pathogenic mechanism that plays an important role in antiviral immunity in plants.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.23897