Mechanical stress-induced cell death in breast cancer cells

Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis. Inducing necrosis is also important in attracting...

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Bibliographic Details
Published in:Biology open 2019, Vol.8 (8)
Main Authors: Takao, Satomi, Taya, Minoru, Chiew, Cerwyn
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Breast cancer cells
Cell death
Cells
Compression
Experiments
Immune system
Literature reviews
Magnetic fields
Mechanical stress-induced cell death (MSICD)
Medical research
Mortality
Nanoparticles
Necrosis
Oscillating compression stress
Shear stress
Stress
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Summary:Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis. Inducing necrosis is also important in attracting more immune cells to the cancer site via the release of danger-associated molecular patterns from cancer cells. Here we applied dynamic compression to breast cancer cells with a low frequency (0.1-30 Hz) and for a short duration (30-300 s) and they resulted in a mixed mode of apoptosis and necrosis dominant with necrotic cell death, which we call mechanical stress-induced cell death (MSICD). The necrotic cell damage of mechanically treated breast cancer cells increased in a force-dependent and time-dependent manner while a trend of frequency-independent MSICD was observed.
ISSN:2046-6390
2046-6390
DOI:10.1242/bio.043133