Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells

Testosterone-related steroid hormones are associated with various types of diseases, including prostate cancer and androgenetic alopecia (AGA). The testosterone or dihydroxy testosterone (DHT) circulates through the blood, binds to the androgen receptor (AR) in the cytoplasm, and finally enters the...

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Bibliographic Details
Published in:Scientific data 2022-11, Vol.9 (1), p.731-731, Article 731
Main Authors: Matsusaka, Himari, Wu, Tao, Furuya, Kai, Yamada-Kato, Tomoe, Bai, Lanlan, Tomita, Hiroshi, Sugano, Eriko, Ozaki, Taku, Kiyono, Tohru, Okunishi, Isao, Fukuda, Tomokazu
Format: Article
Language:English
Subjects:
631/337/2019
631/80/86/2363
692/163/2743/1459
Alopecia
Androgen receptors
Androgens
Cytoplasm
Data Descriptor
Dermis
Humanities and Social Sciences
Humans
Male
Minoxidil
multidisciplinary
Next-generation sequencing
Prostate cancer
RNA-Seq
Science
Science (multidisciplinary)
Signal Transduction
Steroid hormones
Testosterone
Transcriptome
Transcriptomes
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Summary:Testosterone-related steroid hormones are associated with various types of diseases, including prostate cancer and androgenetic alopecia (AGA). The testosterone or dihydroxy testosterone (DHT) circulates through the blood, binds to the androgen receptor (AR) in the cytoplasm, and finally enters the nucleus to activate downstream target genes. We previously found that immortalized dermal papilla cells (DPCs) lost AR expression, which may be explained by the repeated cell passages of DPCs. To compensate for the AR expression, DPCs that express AR exogenously were established. In this study, we performed an RNA-Seq analysis of the AR-expressing and non-AR-expressing DPCs in the presence or absence of DHT to identify the downstream target genes regulated by AR signalling. Furthermore, we treated DPCs with minoxidil sulphate, which has the potential to treat AGA. This is the first comprehensive analysis to identify the downstream genes involved in testosterone signalling in DPCs. Our manuscript provides high-priority data for the discovery of molecular targets for prostate cancer and AGA. Measurement(s) androgen receptor signaling pathway Technology Type(s) Next Generation Sequencing Sample Characteristic - Organism Homo
ISSN:2052-4463
2052-4463
DOI:10.1038/s41597-022-01846-w