Regulation of proteolytic cleavage of brain-derived neurotrophic factor precursor by antidepressants in human neuroblastoma cells

Evidence has supported the role of brain-derived neurotrophic factor (BDNF) in antidepressant effect. The precursor of BDNF (proBDNF) often exerts opposing biological effects on mature BDNF (mBDNF). Hence, the balance between proBDNF and mBDNF might be critical in total neurotrophic effects, leading...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2015-01, Vol.11 (default), p.2529-2532
Main Author: Lin, Pao-Yen
Format: Article
Language:English
Subjects:
Analysis
Antidepressants
Antidepressants, Tricyclic
Apoptosis
Brain-derived neurotrophic factor
Mental depression
Neuroblastoma
Neurotrophic factors
Original Research
Protein expression
Proteins
Psychiatry
Software
Substance abuse treatment
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Summary:Evidence has supported the role of brain-derived neurotrophic factor (BDNF) in antidepressant effect. The precursor of BDNF (proBDNF) often exerts opposing biological effects on mature BDNF (mBDNF). Hence, the balance between proBDNF and mBDNF might be critical in total neurotrophic effects, leading to susceptibility to or recovery from depression. In the current study, we measured the protein expression levels of proBDNF, and its proteolytic products, truncated BDNF, and mBDNF, in human SH-SY5Y cells treated with different antidepressants. We found that the treatment significantly increased the production of mBDNF, but decreased the production of truncated BDNF and proBDNF. These results support that antidepressants can promote proBDNF cleavage. Further studies are needed to clarify whether proBDNF cleavage plays a role in antidepressant mechanisms.
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S87743