Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review

Acetylcholinesterase inhibitors (AChEIs) are an attractive research subject owing to their potential applications in the treatment of neurodegenerative diseases. Fungi and bacteria are major producers of AChEIs. Their active ingredients of fermentation products include alkaloids, terpenoids, phenylp...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-01, Vol.22 (1), p.176
Main Authors: Su, Jingqian, Liu, Huiying, Guo, Kai, Chen, Long, Yang, Minhe, Chen, Qi
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
acetylcholinesterase inhibitors
Alkaloids - pharmacology
Alzheimer Disease - drug therapy
Alzheimer's disease
Bacteria - metabolism
Cholinesterase Inhibitors - analysis
Cholinesterase Inhibitors - isolation & purification
Cholinesterase Inhibitors - therapeutic use
Chromatography
Chromatography, Liquid - methods
Chromatography, Thin Layer - methods
Enzymes
Fermentation
Fungi - metabolism
in vitro assays
Inhibitors
Laboratories
Liquid chromatography
Mass spectrometry
Mass Spectrometry - methods
Mass spectroscopy
Microorganisms
Myasthenia gravis
Nervous system
Phenylpropanoids
Reagents
Review
Scientific imaging
Solvents
Steroid hormones
Thin layer chromatography
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Summary:Acetylcholinesterase inhibitors (AChEIs) are an attractive research subject owing to their potential applications in the treatment of neurodegenerative diseases. Fungi and bacteria are major producers of AChEIs. Their active ingredients of fermentation products include alkaloids, terpenoids, phenylpropanoids, and steroids. A variety of in vitro acetylcholinesterase inhibitor assays have been developed and used to measure the activity of acetylcholinesterases, including modified Ellman's method, thin layer chromatography bioautography, and the combined liquid chromatography-mass spectrometry/modified Ellman's method. In this review, we provide an overview of the different detection methodologies, the microbe-derived AChEIs, and their producing strains.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22010176