Synthesis, Characterization and Antibacterial Activity of Novel 1,3-Diethyl-1,3-bis(4-nitrophenyl)urea and Its Metal(II) Complexes

• Published in: Molecules (Basel, Switzerland) Switzerland), 2017-12, Vol.22 (12), p.2125
• Main Authors: Pasdar, Hoda, Hedayati Saghavaz, Bahare, Foroughifar, Naser, Davallo, Mehran
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Bacteria; broth dilution; Conductance; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Dilution; dinuclear metal(II) complexes; disc diffusion; Drugs; Gram-negative bacteria; Gram-positive bacteria; Humans; In vitro methods and tests; Infrared spectroscopy; Ligands; Mass spectroscopy; Metal complexes; Metals; Metals - chemistry; Microbial Sensitivity Tests - methods; Minimum inhibitory concentration; Molecular Structure; monoclinic system; NMR; Nuclear magnetic resonance; Phenylurea Compounds - chemistry; Phenylurea Compounds - pharmacology; Resistance; Serratia marcescens; Serratia marcescens - drug effects; Spectroscopy; Spectrum analysis; Staphylococcus aureus - drug effects; symmetrical urea; Urea; Zinc; Zinc compounds
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22122125

A bioactive ligand and its dinuclear metal(II) complexes were synthesized and characterized by Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-Visible), nuclear magnetic resonance (¹H-NMR), mass spectroscopy and molar conductance measurements. The ligand has been crystalized in the monoclinic system with a P21/c space group. The biological activities of metal complexes were evaluated using disc diffusion and broth dilution methods. In vitro antibacterial activities of the ligand and their metal complexes were examined against two Gram-positive bacteria ( and ) and two Gram-negative bacteria ( and ) and compared to the standard drugs. It was found that metal complexes displayed much higher antibacterial activities and better inhibitory effects than that of the ligand and standard drugs. Among these complexes, the compound having Zn-metal showed greater antibacterial activity against all four tested bacteria and was more effective against with the zone inhibition diameter of 26 mm and MIC value of 31.25 µg/mL.