Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications

BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patien...

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Bibliographic Details
Published in:Frontiers in oncology 2021-07, Vol.11, p.611218-611218
Main Authors: Maiuri, Francesco, Mariniello, Giuseppe, de Divitiis, Oreste, Esposito, Felice, Guadagno, Elia, Teodonno, Giuseppe, Barbato, Marcello, Del Basso De Caro, Marialaura
Format: Article
Language:English
Subjects:
meningioma
meningioma recurrence
Oncology
progesterone receptor
proliferation index Ki 67 MIB1
WHO grade
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Summary:BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (5 years (p = 0.036). CONCLUSIONThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.611218