Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications

BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patien...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2021-07, Vol.11, p.611218-611218
Main Authors: Maiuri, Francesco, Mariniello, Giuseppe, de Divitiis, Oreste, Esposito, Felice, Guadagno, Elia, Teodonno, Giuseppe, Barbato, Marcello, Del Basso De Caro, Marialaura
Format: Article
Language:English
Subjects:
meningioma
meningioma recurrence
Oncology
progesterone receptor
proliferation index Ki 67 MIB1
WHO grade
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83
cites cdi_FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83
container_end_page 611218
container_issue
container_start_page 611218
container_title Frontiers in oncology
container_volume 11
creator Maiuri, Francesco
Mariniello, Giuseppe
de Divitiis, Oreste
Esposito, Felice
Guadagno, Elia
Teodonno, Giuseppe
Barbato, Marcello
Del Basso De Caro, Marialaura
description BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (5 years (p = 0.036). CONCLUSIONThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance.
doi_str_mv 10.3389/fonc.2021.611218
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_3510382c39084567aa55dcdcb2b7d73b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_3510382c39084567aa55dcdcb2b7d73b</doaj_id><sourcerecordid>2557543713</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83</originalsourceid><addsrcrecordid>eNpVkU1v1DAQhi0EolXpnWOOXHZxPP4KByRUtXSlIioEEpysie2krhI72FkE_75etkLUF1uvZ575eAl53dItgO7eDinaLaOs3cq2Za1-Rk4ZA77pOHx__t_7hJyXck_rkYK2FF6SE-AAUoI8JT9ucxp9WX1O0TdfvPXLmnJz-XvJvpSQYhNi88nHEMeQZizvmltc79KUxmBxajC65kCIqazBNrt5maq-1rzyirwYcCr-_PE-I9-uLr9eXG9uPn_cXXy42VgO3brRlHEpRKc9ImPaMSd7GDi11iGjFhTlgnVOYacVY94PqLke2KAcStuihjOyO3Jdwnuz5DBj_mMSBvNXSHk0mGtzkzcg6viaWeio5kIqRCGcdbZnvXIK-sp6f2Qt-372zvq4ZpyeQJ_-xHBnxvTLaGBUa1kBbx4BOf3c172aORTrpwmjT_timBBKcFAt1FB6DLU5lZL98K9MS83BYHMw2BwMNkeD4QHchZnt</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557543713</pqid></control><display><type>article</type><title>Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications</title><source>PubMed Central</source><creator>Maiuri, Francesco ; Mariniello, Giuseppe ; de Divitiis, Oreste ; Esposito, Felice ; Guadagno, Elia ; Teodonno, Giuseppe ; Barbato, Marcello ; Del Basso De Caro, Marialaura</creator><creatorcontrib>Maiuri, Francesco ; Mariniello, Giuseppe ; de Divitiis, Oreste ; Esposito, Felice ; Guadagno, Elia ; Teodonno, Giuseppe ; Barbato, Marcello ; Del Basso De Caro, Marialaura</creatorcontrib><description>BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (&lt;15%); 2. moderately low (16-50%); 3. moderately high (51-79%); 4. high (≥80%). The PR values were correlated with the patient age and sex, meningioma location, WHO grade, Ki-67 MIB1, recurrence rate, pattern of recurrence (local-peripheral versus multicentric diffuse), and time to recurrence. RESULTSThe PR expression has shown lower rate of high expression in the elderly group (p = 0.032) and no sex difference (including premenopausal versus postmenopausal women), higher expression in medial skull base and spinal versus other locations (p = 0.0036), inverse correlation with WHO grade and Ki67-MIB1 (p &lt; 0.0001). Meningiomas which recurred showed at initial surgery higher rates of low or moderately low PR expression than the non-recurrent ones (p = 0.0004), whereas the pattern of regrowth was not significant. Higher rates of PR values ≥80% were found in cases with time to recurrence &gt;5 years (p = 0.036). CONCLUSIONThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance.</description><identifier>ISSN: 2234-943X</identifier><identifier>EISSN: 2234-943X</identifier><identifier>DOI: 10.3389/fonc.2021.611218</identifier><identifier>PMID: 34336636</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>meningioma ; meningioma recurrence ; Oncology ; progesterone receptor ; proliferation index Ki 67 MIB1 ; WHO grade</subject><ispartof>Frontiers in oncology, 2021-07, Vol.11, p.611218-611218</ispartof><rights>Copyright © 2021 Maiuri, Mariniello, de Divitiis, Esposito, Guadagno, Teodonno, Barbato and Del Basso De Caro 2021 Maiuri, Mariniello, de Divitiis, Esposito, Guadagno, Teodonno, Barbato and Del Basso De Caro</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83</citedby><cites>FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320886/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320886/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Maiuri, Francesco</creatorcontrib><creatorcontrib>Mariniello, Giuseppe</creatorcontrib><creatorcontrib>de Divitiis, Oreste</creatorcontrib><creatorcontrib>Esposito, Felice</creatorcontrib><creatorcontrib>Guadagno, Elia</creatorcontrib><creatorcontrib>Teodonno, Giuseppe</creatorcontrib><creatorcontrib>Barbato, Marcello</creatorcontrib><creatorcontrib>Del Basso De Caro, Marialaura</creatorcontrib><title>Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications</title><title>Frontiers in oncology</title><description>BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (&lt;15%); 2. moderately low (16-50%); 3. moderately high (51-79%); 4. high (≥80%). The PR values were correlated with the patient age and sex, meningioma location, WHO grade, Ki-67 MIB1, recurrence rate, pattern of recurrence (local-peripheral versus multicentric diffuse), and time to recurrence. RESULTSThe PR expression has shown lower rate of high expression in the elderly group (p = 0.032) and no sex difference (including premenopausal versus postmenopausal women), higher expression in medial skull base and spinal versus other locations (p = 0.0036), inverse correlation with WHO grade and Ki67-MIB1 (p &lt; 0.0001). Meningiomas which recurred showed at initial surgery higher rates of low or moderately low PR expression than the non-recurrent ones (p = 0.0004), whereas the pattern of regrowth was not significant. Higher rates of PR values ≥80% were found in cases with time to recurrence &gt;5 years (p = 0.036). CONCLUSIONThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance.</description><subject>meningioma</subject><subject>meningioma recurrence</subject><subject>Oncology</subject><subject>progesterone receptor</subject><subject>proliferation index Ki 67 MIB1</subject><subject>WHO grade</subject><issn>2234-943X</issn><issn>2234-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1v1DAQhi0EolXpnWOOXHZxPP4KByRUtXSlIioEEpysie2krhI72FkE_75etkLUF1uvZ575eAl53dItgO7eDinaLaOs3cq2Za1-Rk4ZA77pOHx__t_7hJyXck_rkYK2FF6SE-AAUoI8JT9ucxp9WX1O0TdfvPXLmnJz-XvJvpSQYhNi88nHEMeQZizvmltc79KUxmBxajC65kCIqazBNrt5maq-1rzyirwYcCr-_PE-I9-uLr9eXG9uPn_cXXy42VgO3brRlHEpRKc9ImPaMSd7GDi11iGjFhTlgnVOYacVY94PqLke2KAcStuihjOyO3Jdwnuz5DBj_mMSBvNXSHk0mGtzkzcg6viaWeio5kIqRCGcdbZnvXIK-sp6f2Qt-372zvq4ZpyeQJ_-xHBnxvTLaGBUa1kBbx4BOf3c172aORTrpwmjT_timBBKcFAt1FB6DLU5lZL98K9MS83BYHMw2BwMNkeD4QHchZnt</recordid><startdate>20210715</startdate><enddate>20210715</enddate><creator>Maiuri, Francesco</creator><creator>Mariniello, Giuseppe</creator><creator>de Divitiis, Oreste</creator><creator>Esposito, Felice</creator><creator>Guadagno, Elia</creator><creator>Teodonno, Giuseppe</creator><creator>Barbato, Marcello</creator><creator>Del Basso De Caro, Marialaura</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210715</creationdate><title>Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications</title><author>Maiuri, Francesco ; Mariniello, Giuseppe ; de Divitiis, Oreste ; Esposito, Felice ; Guadagno, Elia ; Teodonno, Giuseppe ; Barbato, Marcello ; Del Basso De Caro, Marialaura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>meningioma</topic><topic>meningioma recurrence</topic><topic>Oncology</topic><topic>progesterone receptor</topic><topic>proliferation index Ki 67 MIB1</topic><topic>WHO grade</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maiuri, Francesco</creatorcontrib><creatorcontrib>Mariniello, Giuseppe</creatorcontrib><creatorcontrib>de Divitiis, Oreste</creatorcontrib><creatorcontrib>Esposito, Felice</creatorcontrib><creatorcontrib>Guadagno, Elia</creatorcontrib><creatorcontrib>Teodonno, Giuseppe</creatorcontrib><creatorcontrib>Barbato, Marcello</creatorcontrib><creatorcontrib>Del Basso De Caro, Marialaura</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Frontiers in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maiuri, Francesco</au><au>Mariniello, Giuseppe</au><au>de Divitiis, Oreste</au><au>Esposito, Felice</au><au>Guadagno, Elia</au><au>Teodonno, Giuseppe</au><au>Barbato, Marcello</au><au>Del Basso De Caro, Marialaura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications</atitle><jtitle>Frontiers in oncology</jtitle><date>2021-07-15</date><risdate>2021</risdate><volume>11</volume><spage>611218</spage><epage>611218</epage><pages>611218-611218</pages><issn>2234-943X</issn><eissn>2234-943X</eissn><abstract>BACKGROUNDThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed. METHODSA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (&lt;15%); 2. moderately low (16-50%); 3. moderately high (51-79%); 4. high (≥80%). The PR values were correlated with the patient age and sex, meningioma location, WHO grade, Ki-67 MIB1, recurrence rate, pattern of recurrence (local-peripheral versus multicentric diffuse), and time to recurrence. RESULTSThe PR expression has shown lower rate of high expression in the elderly group (p = 0.032) and no sex difference (including premenopausal versus postmenopausal women), higher expression in medial skull base and spinal versus other locations (p = 0.0036), inverse correlation with WHO grade and Ki67-MIB1 (p &lt; 0.0001). Meningiomas which recurred showed at initial surgery higher rates of low or moderately low PR expression than the non-recurrent ones (p = 0.0004), whereas the pattern of regrowth was not significant. Higher rates of PR values ≥80% were found in cases with time to recurrence &gt;5 years (p = 0.036). CONCLUSIONThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance.</abstract><pub>Frontiers Media S.A</pub><pmid>34336636</pmid><doi>10.3389/fonc.2021.611218</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2234-943X
ispartof Frontiers in oncology, 2021-07, Vol.11, p.611218-611218
issn 2234-943X
2234-943X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_3510382c39084567aa55dcdcb2b7d73b
source PubMed Central
subjects meningioma
meningioma recurrence
Oncology
progesterone receptor
proliferation index Ki 67 MIB1
WHO grade
title Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T18%3A18%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Progesterone%20Receptor%20Expression%20in%20Meningiomas:%20Pathological%20and%20Prognostic%20Implications&rft.jtitle=Frontiers%20in%20oncology&rft.au=Maiuri,%20Francesco&rft.date=2021-07-15&rft.volume=11&rft.spage=611218&rft.epage=611218&rft.pages=611218-611218&rft.issn=2234-943X&rft.eissn=2234-943X&rft_id=info:doi/10.3389/fonc.2021.611218&rft_dat=%3Cproquest_doaj_%3E2557543713%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c439t-802465598eaa228d2d6b3f40ccda20c3704529d7a98722eefa848f2f7da6c1a83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2557543713&rft_id=info:pmid/34336636&rfr_iscdi=true