Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness

• Published in: Frontiers in neuroscience 2020-04, Vol.14, p.294-294
• Main Authors: Murovec, Nensi, Heilinger, Alexander, Xu, Ren, Ortner, Rupert, Spataro, Rossella, La Bella, Vincenzo, Miao, Yangyang, Jin, Jing, Chatelle, Camille, Laureys, Steven, Allison, Brendan Z, Guger, Christoph
• Format: Article
• Language: English
• Subjects: Accuracy; Age; BCI performance; Brain; Classification; Cognitive ability; Coma; Communication; Computer applications; Consciousness; CRS-R; Data analysis; disorders of consciousness; Electrodes; Event-related potentials; Implants; Interfaces; Neuroscience; Neurosciences & behavior; Neurosciences & comportement; P300 event-related potential; Patients; Sciences sociales & comportementales, psychologie; Social & behavioral sciences, psychology; tactile stimulation
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2020.00294

Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients' cognitive functions and command following abilities. 20 DOC patients participated in the study and performed 10 vibro-tactile P300 BCI sessions over 10 days with 8-12 runs each day. Vibrotactile tactors were placed on the each patient's left and right wrists and one foot. Patients were instructed, via earbuds, to concentrate and silently count vibrotactile pulses on either their left or right wrist that presented a target stimulus and to ignore the others. Changes of the BCI classification accuracy were investigated over the 10 days. In addition, the Coma Recovery Scale-Revised (CRS-R) score was measured before and after the 10 vibro-tactile P300 sessions. In the first run, 10 patients had a classification accuracy above chance level (>12.5%). In the best run, every patient reached an accuracy ≥60%. The grand average accuracy in the first session for all patients was 40%. In the best session, the grand average accuracy was 88% and the median accuracy across all sessions was 21%. The CRS-R scores compared before and after 10 VT3 sessions for all 20 patients, are showing significant improvement ( = 0.024). Twelve of the twenty patients showed an improvement of 1 to 7 points in the CRS-R score after the VT3 BCI sessions (mean: 2.6). Six patients did not show a change of the CRS-R and two patients showed a decline in the score by 1 point. Every patient achieved at least 60% accuracy at least once, which indicates successful command following. This shows the importance of repeated measures when DOC patients are assessed. The improvement of the CRS-R score after the 10 VT3 sessions is an important issue for future experiments to test the possible therapeutic applications of vibro-tactile and related BCIs with a larger patient group.