Association between Gallstone Disease and Statin Use: A Nested Case-Control Study in Korea

The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case-control study using data from the Korean N...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-04, Vol.16 (4), p.536
Main Authors: Kwon, Mi Jung, Lee, Jung Woo, Kang, Ho Suk, Lim, Hyun, Kim, Eun Soo, Kim, Nan Young, Choi, Hyo Geun, Kim, Min-Jeong
Format: Article
Language:English
Subjects:
Blood pressure
Cholesterol
Cohort analysis
Comorbidity
Confounding (Statistics)
Disease prevention
Dosage and administration
Drug therapy
gallstone disease
Gallstones
Gastrointestinal surgery
hydrophilic statin
lipophilic statin
Metabolism
nested case—control study
Pancreatitis
Patients
Population
Prevention
Risk factors
Statins
Testing
Validation studies
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Summary:The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case-control study using data from the Korean National Health Insurance Service Health Screening Cohort (2002-2019) to determine the likelihood of gallstone disease according to periods of previous statin use and type of statin. Among the 514,866 participants, 22,636 diagnosed with gallstones at ≥2 clinic visits (using the International Classification of Diseases, 10th revision, code K80) were matched 1:4 to 90,544 controls for age, sex, income, and residential area, and their statin prescription history for 2 years prior to the index date was examined. Propensity-score-weighted odds ratios (ORs) for gallstone disease were calculated using conditional logistic regression. Long-term use (>545 days) of any statin or lipophilic statins was associated with lower odds of incident gallstones (OR = 0.91, 95% confidence interval [CI] = 0.86-0.96, < 0.001 and OR = 0.88, 95% CI = 0.83-0.93, < 0.001, respectively) after adjusting for confounders. Short-term use (180-545 days) of any statin or hydrophilic statins was not statistically related to incident gallstones. In summary, prior statin medication, particularly long-term lipophilic statin use, may confer a preventive advantage against gallstone disease.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16040536