Erythropoetin receptor expression in the human diabetic retina

Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseas...

Full description

Saved in:
Bibliographic Details
Published in:BMC research notes 2009-11, Vol.2 (1), p.234-234
Main Authors: Shah, Shaival S, Tsang, Stephen H, Mahajan, Vinit B
Format: Article
Language:English
Subjects:
Development and progression
Diabetes
Diabetic retinopathy
Erythropoietin
Gene expression
Hypoxia
Ischemia
Physiological aspects
Retina
Rodents
Short Report
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseases. This study was performed to identify EPOR mRNA expression in the human diabetic eye. EPOR antisense RNA probes were validated on human pancreas tissue. In the normal eye, EPOR was expressed in the retinal ganglion cell layer. Minimal expression was observed in the inner and outer nuclear layer. Under conditions of diabetic retinopathy, EPOR expression shifted to photoreceptor cells. Increased expression was also observed in the peripheral retina. EPOR expression may be a biomarker or contribute to disease mechanisms in diabetic retinopathy.
ISSN:1756-0500
1756-0500
DOI:10.1186/1756-0500-2-234