Pulmonary Involvement during the Ebola Virus Disease

Filoviruses have become a worldwide public health concern, especially during the 2013-2016 Western Africa Ebola virus disease (EVD) outbreak-the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several org...

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Bibliographic Details
Published in:Viruses 2019-08, Vol.11 (9), p.780
Main Authors: Lalle, Eleonora, Biava, Mirella, Nicastri, Emanuele, Colavita, Francesca, Di Caro, Antonino, Vairo, Francesco, Lanini, Simone, Castilletti, Concetta, Langer, Martin, Zumla, Alimuddin, Kobinger, Gary, Capobianchi, Maria R, Ippolito, Giuseppe
Format: Article
Language:English
Subjects:
Africa, Western - epidemiology
Animals
Chemokines
Cytokines
Defense mechanisms
Disease
Disease Outbreaks
Ebola virus
Ebola virus disease
Ebolavirus
Ebolavirus - isolation & purification
Ebolavirus - pathogenicity
Epidemics
Fatalities
Female
Hemorrhagic Fever, Ebola - immunology
Hemorrhagic Fever, Ebola - pathology
Hemorrhagic Fever, Ebola - transmission
Humans
Immune system
Infections
Inflammation
Lung - pathology
Lung - virology
lung pathogenesis
Lungs
Male
Outbreaks
Pathogenesis
Public health
respiratory disease
Respiratory Tract Infections - immunology
Respiratory Tract Infections - virology
Review
Viruses
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Summary:Filoviruses have become a worldwide public health concern, especially during the 2013-2016 Western Africa Ebola virus disease (EVD) outbreak-the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013-2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013-2016 Ebola outbreak.
ISSN:1999-4915
1999-4915
DOI:10.3390/v11090780