Recurrent brain tumor versus radiation necrosis; can dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging differentiate?

Assessment of treatment response in patients with a brain tumor is paramount, as true tumor recurrence and radiation necrosis are similar looking on conventional MRI. To evaluate the role of dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging in the differentiation between rec...

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Bibliographic Details
Published in:Egyptian journal of radiology and nuclear medicine 2018-09, Vol.49 (3), p.719-726
Main Authors: Soliman, Heba M., ElBeheiry, Ahmed A., Abdel-Kerim, Amr A., Farhoud, Ahmed H., Reda, M. Ihab
Format: Article
Language:English
Subjects:
Cerebral blood volume
Dynamic susceptibility contrast
MR perfusion
Peak height
Recurrent brain tumors
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Summary:Assessment of treatment response in patients with a brain tumor is paramount, as true tumor recurrence and radiation necrosis are similar looking on conventional MRI. To evaluate the role of dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging in the differentiation between recurrent brain tumors and radiation necrosis. Twenty patients with a history of operated primary brain tumors and postoperative radiotherapy with or without chemotherapy were enrolled in this prospective study having conventional MRI findings of enhancing lesion suspicious of being recurrence or radiation necrosis. All patients were examined by DSC-perfusion MRI. Definitive diagnosis was reached through either subsequent surgical biopsy or follow up over 6-12 months. Fifteen patients (75%) were diagnosed as tumor recurrence and 5 patients as radiation necrosis (25%). The relative cerebral blood volume (rCBV) and relative peak height (rPH) were significantly higher (P 
ISSN:0378-603X
DOI:10.1016/j.ejrnm.2018.03.013