JNK signalling regulates antioxidant responses in neurons

Reactive oxygen species (ROS) are generated during physiological bouts of synaptic activity and as a consequence of pathological conditions in the central nervous system. How neurons respond to and distinguish between ROS in these different contexts is currently unknown. In Drosophila mutants with e...

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Bibliographic Details
Published in:Redox biology 2020-10, Vol.37, p.101712-101712, Article 101712
Main Authors: Ugbode, Chris, Garnham, Nathan, Fort-Aznar, Laura, Evans, Gareth J.O., Chawla, Sangeeta, Sweeney, Sean T.
Format: Article
Language:English
Subjects:
Drosophila
Glutathione
Hydrogen Peroxide
Research Paper
ROS
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Summary:Reactive oxygen species (ROS) are generated during physiological bouts of synaptic activity and as a consequence of pathological conditions in the central nervous system. How neurons respond to and distinguish between ROS in these different contexts is currently unknown. In Drosophila mutants with enhanced JNK activity, lower levels of ROS are observed and these animals are resistant to both changes in ROS and changes in synapse morphology induced by oxidative stress. In wild type flies, disrupting JNK-AP-1 signalling perturbs redox homeostasis suggesting JNK activity positively regulates neuronal antioxidant defense. We validated this hypothesis in mammalian neurons, finding that JNK activity regulates the expression of the antioxidant gene Srxn-1, in a c-Jun dependent manner. We describe a conserved ‘adaptive’ role for neuronal JNK in the maintenance of redox homeostasis that is relevant to several neurodegenerative diseases.
ISSN:2213-2317
2213-2317
DOI:10.1016/j.redox.2020.101712