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Harnessing exosomes as cancer biomarkers in clinical oncology
Exosomes are extracellular vesicles well known for facilitating cell-to-cell communication by distributing essential macromolecules like proteins, DNA, mRNA, lipids, and miRNA. These vesicles are abundant in fluids distributed throughout the body, including urine, blood, saliva, and even bile. They...
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| Published in: | Cancer cell international 2024-08, Vol.24 (1), p.278-26, Article 278 |
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| container_title | Cancer cell international |
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| creator | Ghosh, Subhrojyoti Rajendran, Ramya Lakshmi Mahajan, Atharva A Chowdhury, Ankita Bera, Aishi Guha, Sudeepta Chakraborty, Kashmira Chowdhury, Rajanyaa Paul, Aritra Jha, Shreya Dey, Anuvab Dubey, Amit Gorai, Sukhamoy Das, Purbasha Hong, Chae Moon Krishnan, Anand Gangadaran, Prakash Ahn, Byeong-Cheol |
| description | Exosomes are extracellular vesicles well known for facilitating cell-to-cell communication by distributing essential macromolecules like proteins, DNA, mRNA, lipids, and miRNA. These vesicles are abundant in fluids distributed throughout the body, including urine, blood, saliva, and even bile. They are important diagnostic tools for breast, lung, gastrointestinal cancers, etc. However, their application as cancer biomarkers has not yet been implemented in most parts of the world. In this review, we discuss how OMICs profiling of exosomes can be practiced by substituting traditional imaging or biopsy methods for cancer detection. Previous methods like extensive imaging and biopsy used for screening were expensive, mostly invasive, and could not easily provide early detection for various types of cancer. Exosomal biomarkers can be utilized for routine screening by simply collecting body fluids from the individual. We anticipate that the use of exosomes will be brought to light by the success of clinical trials investigating their potential to enhance cancer detection and treatment in the upcoming years. |
| doi_str_mv | 10.1186/s12935-024-03464-5 |
| format | article |
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These vesicles are abundant in fluids distributed throughout the body, including urine, blood, saliva, and even bile. They are important diagnostic tools for breast, lung, gastrointestinal cancers, etc. However, their application as cancer biomarkers has not yet been implemented in most parts of the world. In this review, we discuss how OMICs profiling of exosomes can be practiced by substituting traditional imaging or biopsy methods for cancer detection. Previous methods like extensive imaging and biopsy used for screening were expensive, mostly invasive, and could not easily provide early detection for various types of cancer. Exosomal biomarkers can be utilized for routine screening by simply collecting body fluids from the individual. We anticipate that the use of exosomes will be brought to light by the success of clinical trials investigating their potential to enhance cancer detection and treatment in the upcoming years.</description><identifier>ISSN: 1475-2867</identifier><identifier>EISSN: 1475-2867</identifier><identifier>DOI: 10.1186/s12935-024-03464-5</identifier><identifier>PMID: 39113040</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Antigens ; Biomarkers ; Biopsy ; Biosynthesis ; Body fluids ; Cancer ; Cancer biomarkers ; Cancer therapies ; Cell interactions ; Clinical signature ; Clinical trials ; CRISPR ; Cytotoxicity ; Diagnostic tool ; Enzymes ; Exosomes ; Extracellular matrix ; Lipids ; Medical research ; Metastasis ; MicroRNAs ; miRNA ; mRNA ; Precision medicine ; Prognostic indicator ; Proteins ; Review ; Roles ; Saliva ; Tumor-derived exosomes ; Tumors ; Vesicles</subject><ispartof>Cancer cell international, 2024-08, Vol.24 (1), p.278-26, Article 278</ispartof><rights>2024. The Author(s).</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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These vesicles are abundant in fluids distributed throughout the body, including urine, blood, saliva, and even bile. They are important diagnostic tools for breast, lung, gastrointestinal cancers, etc. However, their application as cancer biomarkers has not yet been implemented in most parts of the world. In this review, we discuss how OMICs profiling of exosomes can be practiced by substituting traditional imaging or biopsy methods for cancer detection. Previous methods like extensive imaging and biopsy used for screening were expensive, mostly invasive, and could not easily provide early detection for various types of cancer. Exosomal biomarkers can be utilized for routine screening by simply collecting body fluids from the individual. 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| ispartof | Cancer cell international, 2024-08, Vol.24 (1), p.278-26, Article 278 |
| issn | 1475-2867 1475-2867 |
| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Antigens Biomarkers Biopsy Biosynthesis Body fluids Cancer Cancer biomarkers Cancer therapies Cell interactions Clinical signature Clinical trials CRISPR Cytotoxicity Diagnostic tool Enzymes Exosomes Extracellular matrix Lipids Medical research Metastasis MicroRNAs miRNA mRNA Precision medicine Prognostic indicator Proteins Review Roles Saliva Tumor-derived exosomes Tumors Vesicles |
| title | Harnessing exosomes as cancer biomarkers in clinical oncology |
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