High blood pressure and overweight in children with Legg-Calvé-Perthes disease: a nationwide population-based cohort study

• Published in: BMC musculoskeletal disorders 2021-01, Vol.22 (1), p.32-32, Article 32
• Main Authors: Mörlin, Gabriella B, Hailer, Yasmin D
• Format: Article
• Language: English
• Subjects: Age; Blood pressure; BMI; Body mass index; Body weight; Cardiovascular diseases; Child; Children; Children & youth; Classification; Cohort analysis; Cohort Studies; Disease; Etiology; Humans; Hypertension; Hypertension - diagnosis; Hypertension - epidemiology; Legg-Calve-Perthes disease; Legg-Calve-Perthes Disease - diagnostic imaging; Legg-Calve-Perthes Disease - epidemiology; Legg-Calvé-Perthes disease; Musculoskeletal diseases; Obesity; Osteochondrosis; Overweight; Pediatrics; Population; Population studies; Population-based studies; Prevalence; Register; Sensitivity analysis; Sex; Sweden - epidemiology
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-020-03889-9

Legg-Calvé-Perthes disease (LCPD) and its association with cardiovascular diseases, obesity and hypertension has been consistently observed but remains cloudy. This study aimed to investigate the presence of hypertension and overweight/obesity at diagnosis of LCPD and at a 2-year follow-up and its association with age, sex and lateral pillar classification. We compared blood pressure (BP) (n = 93) and body mass index (BMI) (n = 125) in patients registered in the Perthes' register - a part of the Swedish pediatric orthopedic quality register (SPOQ) - with normative data for children with the same age and sex. In children with LCPD 19% had high BP. At the 2-year follow-up, 13% had high BP. For children with LCPD, 30% were either overweight or obese. At the 2-year follow-up, 32% were either overweight or obese. Paired analysis showed stable BMI z-score between these 2 measurements. The sample size of this study was too small to analyze possible associations of high BP or BMI with age, sex and lateral pillar classification. The prevalence of hypertension was higher in children with LCPD compared to general pediatric normative data. The same pattern was seen for overweight/obesity. Further studies are needed to investigate whether BP and obesity are catalyzing factors in the etiology of LCPD.