TMS for staging and predicting functional decline in frontotemporal dementia

To evaluate if transcranial magnetic stimulation (TMS) measures correlate with disease severity and predict functional decline in frontotemporal dementia (FTD) phenotypes. Paired-pulse TMS was used to investigate the activity of different intracortical circuits in 171 FTD patients (122 bvFTD, 31 avP...

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Bibliographic Details
Published in:Brain stimulation 2020-03, Vol.13 (2), p.386-392
Main Authors: Benussi, Alberto, Dell’Era, Valentina, Cantoni, Valentina, Cotelli, Maria Sofia, Cosseddu, Maura, Spallazzi, Marco, Micheli, Anna, Turrone, Rosanna, Alberici, Antonella, Borroni, Barbara
Format: Article
Language:English
Subjects:
Frontotemporal dementia
Long interval intracortical inhibition
Prognosis
Progression
Short interval intracortical inhibition-intracortical facilitation
Transcranial magnetic stimulation
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Summary:To evaluate if transcranial magnetic stimulation (TMS) measures correlate with disease severity and predict functional decline in frontotemporal dementia (FTD) phenotypes. Paired-pulse TMS was used to investigate the activity of different intracortical circuits in 171 FTD patients (122 bvFTD, 31 avPPA, 18 svPPA) and 74 healthy controls. Pearson’s correlations were used to analyze the association between TMS measures and disease severity, while multiple regression analysis was used to identify the best clinical or neurophysiological measure to predict functional decline at 12 months. We observed significant strong correlations between TMS measures [short interval intracortical inhibition-facilitation (SICI-ICF) and long interval intracortical inhibition (LICI)], and disease severity (evaluated with the FTLD-CDR) (all r > 0.5, p 
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2019.11.009