Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisp...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-07, Vol.29 (14), p.3246
Main Authors: Mukusheva, Gulim K, Jalmakhanbetova, Roza I, Shaibek, Altynay Zh, Nurmaganbetova, Manshuk S, Zhasymbekova, Aigerym R, Nurkenov, Oralgazy A, Akishina, Ekaterina A, Kolesnik, Irina A, Dikusar, Evgenij A, Terpinskaya, Tatiana I, Kulchitsky, Vladimir A, Potkin, Vladimir I, Pushkarchuk, Alexander L, Lyakhov, Dmitry A, Michels, Dominik L
Format: Article
Language:English
Subjects:
Alkaloids - chemical synthesis
Alkaloids - chemistry
Alkaloids - pharmacology
anabasine
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antiproliferative activity
Cancer
Cell Line, Tumor
Cell Proliferation - drug effects
Chemotherapy
cytisine
cytotoxic activity
Drug dosages
Glioma
Glioma - drug therapy
Glioma - pathology
Hydrogen bonds
isoxazole
Molecular Docking Simulation
Rats
Toxicity
Urea - analogs & derivatives
Urea - chemistry
Urea - pharmacology
ureas
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Summary:Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29143246