Tardive Dyskinesia-like Syndrome Due to Drugs that do not Block Dopamine Receptors: Rare or Non-existent: Literature Review

BackgroundAlthough tardive dyskinesia (TD) is most commonly defined as a movement disorder caused by chronic exposure to dopamine-receptor-blocking drugs (DRBDs), it has also been thought to result from exposure to some non-DRBDs. MethodsWe critiqued many reviews making the association between non-D...

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Bibliographic Details
Published in:Tremor and other hyperkinetic movements (New York, N.Y.) N.Y.), 2018, Vol.8, p.570-570
Main Authors: D'Abreu, Anelyssa, Friedman, Joseph H
Format: Article
Language:English
Subjects:
Anticholinergics
Antidepressants
Antiepileptics
Antihistamine
Non-dopamine receptor antagonists
Reviews
Tarditive Dyskinesia
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Summary:BackgroundAlthough tardive dyskinesia (TD) is most commonly defined as a movement disorder caused by chronic exposure to dopamine-receptor-blocking drugs (DRBDs), it has also been thought to result from exposure to some non-DRBDs. MethodsWe critiqued many reviews making the association between non-DRBDs and a TD-like syndrome and almost all case reports. We checked whether cases met criteria for the diagnosis of TD-like syndrome and whether DRBDs had been excluded. ResultsWe found that both tricyclic antidepressants and selective serotonin reuptake inhibitor antidepressants may unmask or exacerbate TD after prior exposure to or with concurrent use of DRBDs. We found support for its existence outside of this context to be extremely weak. DiscussionThere is little evidence that drugs other than DRBDs by themselves cause a TD syndrome; most reported cases appear to occur as a result of a "priming" effect induced by a DRBD, which is later unmasked.
ISSN:2160-8288
2160-8288
DOI:10.7916/D8FF58Z9