A green approach for the multicomponent synthesis of polyhydroquinolines and 6-unsubstituted dihydropyrimidinones using novel highly proficient acidic ionic liquid [CEMIM][MSA] as a reusable catalyst

• Published in: Catalysis communications 2022-10, Vol.170, p.106500, Article 106500
• Main Authors: Patil, Priyanka, Kadam, Suresh, Patil, Dayanand, More, Paresh
• Format: Article
• Language: English
• Subjects: Acidic ionic liquid; Dihydropyrimidinones; Green media; Multicomponent reaction; Polyhydroquinolines
• ISSN: 1566-7367; 1873-3905
• DOI: 10.1016/j.catcom.2022.106500

Carboxylic acid functionalized imidazolium based novel acidic ionic liquid [CEMIM][MSA] was synthesized using economically feasible raw materials under very mild condition. The cost effective and sustainable synthesis of polyhydroquinoline and 6-unsustituted dihydropyrimidinone derivatives in green media was first time carried out very effectively using [CEMIM][MSA] catalyst. Acidic ionic liquid catalyst [CEMIM][MSA] with carboxylic acid group was easily separated and reused up to five cycles without much loss in its catalytic activity and stability. The introduced catalyst had showed a better catalytic performance in aqueous medium to obtain described compounds with excellent yields in shorter time. Purification free isolation of pure polyhydroquinolines and 6-unsustituted dihydropyrimidinones derivative makes the revealed protocol attractive and ecological. [Display omitted] •Design and synthesis of novel, reusable and highly proficient acidic ionic liquid catalyst.•First time implemented as catalyst for the synthesis of polyhydroquinolines and 6-unsubstituted dihydropyrimidinones.•Easily separation and reuse of catalyst without loss its chemical stability.•Work up less isolation of pure polyhydroquinolines and 6-unsubstituted dihydropyrimidinones in shorter time.