NMR Spectroscopy of supramolecular chemistry on protein surfaces

As one of the few analytical methods that offer atomic resolution, NMR spectroscopy is a valuable tool to study the interaction of proteins with their interaction partners, both biomolecules and synthetic ligands. In recent years, the focus in chemistry has kept expanding from targeting small bindin...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2020-10, Vol.16 (1), p.2505-2522
Main Authors: Bayer, Peter, Matena, Anja, Beuck, Christine
Format: Article
Language:English
Subjects:
Chemistry
molecular recognition
nmr
protein ligand interaction
protein surfaces
Review
supramolecular chemistry
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Summary:As one of the few analytical methods that offer atomic resolution, NMR spectroscopy is a valuable tool to study the interaction of proteins with their interaction partners, both biomolecules and synthetic ligands. In recent years, the focus in chemistry has kept expanding from targeting small binding pockets in proteins to recognizing patches on protein surfaces, mostly via supramolecular chemistry, with the goal to modulate protein-protein interactions. Here we present NMR methods that have been applied to characterize these molecular interactions and discuss the challenges of this endeavor.
ISSN:1860-5397
1860-5397
DOI:10.3762/BJOC.16.203