Chaperonin GroEL/GroES over-expression promotes multi-drug resistance in E. coli following exposure to aminoglycoside antibiotics

Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antiobiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and overexpression sensitize and promote short-term t...

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Bibliographic Details
Published in:Frontiers in microbiology 2016-01, Vol.6
Main Authors: Lise eGoltermann, Menachem Viktor Sarusie, Thomas eBentin
Format: Article
Language:English
Subjects:
Aminoglycosides
antibiotic resistance
chaperonin
mRNA translation
protein misfolding
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Summary:Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antiobiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and overexpression sensitize and promote short-term tolerance, respectively, to this drug class. Here we show that chaperonin GroEL/GroES over-expression accelerates acquisition of aminoglycoside resistance and multi-drug resistance following sub-lethal aminoglycoside antibiotic exposure. Chaperonin buffering could provide a novel mechanism for antibiotic resistance and multi-drug resistance development.
ISSN:1664-302X
DOI:10.3389/fmicb.2015.01572