Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran

To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population. Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regi...

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Bibliographic Details
Published in:Journal of ophthalmic & vision research 2020-01, Vol.15 (1), p.45-52
Main Authors: Yousefian, Ali, Shokoohi-Rad, Saeed, Abbaszadegan, Mohammad Reza, Rad, Dorsa Morshedi, Zargari, Selma, Milanizadeh, Saman, Morovatdar, Negar, Daneshvar, Ramin
Format: Article
Language:English
Subjects:
Original
polymorphism
primary angle closure glaucoma
rs1258267
rs3816415
rs736893
rs7494379
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Summary:To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population. Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetra-amplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method. Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5 6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0 5.7 years were selected for evaluation. There was a significant association between rs3816415 ( = 0.005), rs736893 ( 0.001), rs7494379 ( 0.001), and rs1258267 ( = 0.02) with PACG susceptibility. This association could not be shown for rs3739821. It was revealed that studied variants in and genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate .
ISSN:2008-2010
2008-322X
DOI:10.18502/jovr.v15i1.5942