Current Status on Stem Cells and Cancers of the Gastric Epithelium

Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self...

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Bibliographic Details
Published in:International journal of molecular sciences 2015-08, Vol.16 (8), p.19153-19169
Main Author: Hoffmann, Werner
Format: Article
Language:English
Subjects:
Adenocarcinoma - microbiology
Adenocarcinoma - pathology
Animals
Bacteria
cancer stem cell
cell differentiation
Gastric cancer
gastric mucosa
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
gastric self-renewal
gastric stem cell
Helicobacter Infections - complications
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori
Helicobacter pylori - isolation & purification
Humans
Infections
metaplasia
Neoplastic Stem Cells - microbiology
Neoplastic Stem Cells - pathology
Review
SPEM
Stem cells
Stomach - microbiology
Stomach - pathology
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
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Summary:Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self-renewal and carcinogenesis are intimately linked, particularly during chronic inflammatory conditions. Generally, gastric cancer is now regarded as a disease resulting from dysregulated differentiation of stem and progenitor cells, mainly due to an inflammatory environment. However, the situation in the stomach is rather complex, consisting of two types of gastric units which show bidirectional self-renewal from an unexpectedly large variety of progenitor/stem cell populations. As in many other tumors, cancer stem cells have also been characterized for gastric cancer. This review focuses on the various gastric epithelial stem cells, how they contribute to self-renewal and which routes are known to gastric adenocarcinomas, including their stem cells.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms160819153