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Current Status on Stem Cells and Cancers of the Gastric Epithelium
Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self...
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| Published in: | International journal of molecular sciences 2015-08, Vol.16 (8), p.19153-19169 |
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| creator | Hoffmann, Werner |
| description | Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self-renewal and carcinogenesis are intimately linked, particularly during chronic inflammatory conditions. Generally, gastric cancer is now regarded as a disease resulting from dysregulated differentiation of stem and progenitor cells, mainly due to an inflammatory environment. However, the situation in the stomach is rather complex, consisting of two types of gastric units which show bidirectional self-renewal from an unexpectedly large variety of progenitor/stem cell populations. As in many other tumors, cancer stem cells have also been characterized for gastric cancer. This review focuses on the various gastric epithelial stem cells, how they contribute to self-renewal and which routes are known to gastric adenocarcinomas, including their stem cells. |
| doi_str_mv | 10.3390/ijms160819153 |
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Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self-renewal and carcinogenesis are intimately linked, particularly during chronic inflammatory conditions. Generally, gastric cancer is now regarded as a disease resulting from dysregulated differentiation of stem and progenitor cells, mainly due to an inflammatory environment. However, the situation in the stomach is rather complex, consisting of two types of gastric units which show bidirectional self-renewal from an unexpectedly large variety of progenitor/stem cell populations. As in many other tumors, cancer stem cells have also been characterized for gastric cancer. This review focuses on the various gastric epithelial stem cells, how they contribute to self-renewal and which routes are known to gastric adenocarcinomas, including their stem cells.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms160819153</identifier><identifier>PMID: 26287172</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenocarcinoma - microbiology ; Adenocarcinoma - pathology ; Animals ; Bacteria ; cancer stem cell ; cell differentiation ; Gastric cancer ; gastric mucosa ; Gastric Mucosa - microbiology ; Gastric Mucosa - pathology ; gastric self-renewal ; gastric stem cell ; Helicobacter Infections - complications ; Helicobacter Infections - microbiology ; Helicobacter Infections - pathology ; Helicobacter pylori ; Helicobacter pylori - isolation & purification ; Humans ; Infections ; metaplasia ; Neoplastic Stem Cells - microbiology ; Neoplastic Stem Cells - pathology ; Review ; SPEM ; Stem cells ; Stomach - microbiology ; Stomach - pathology ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology</subject><ispartof>International journal of molecular sciences, 2015-08, Vol.16 (8), p.19153-19169</ispartof><rights>Copyright MDPI AG 2015</rights><rights>2015 by the authors; licensee MDPI, Basel, Switzerland. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-cb2c27d1b8b7400c8c0e25cadeef355e97621d91551daaedb0c6d308ce7cdf313</citedby><cites>FETCH-LOGICAL-c580t-cb2c27d1b8b7400c8c0e25cadeef355e97621d91551daaedb0c6d308ce7cdf313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1792822876/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1792822876?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26287172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoffmann, Werner</creatorcontrib><title>Current Status on Stem Cells and Cancers of the Gastric Epithelium</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self-renewal and carcinogenesis are intimately linked, particularly during chronic inflammatory conditions. Generally, gastric cancer is now regarded as a disease resulting from dysregulated differentiation of stem and progenitor cells, mainly due to an inflammatory environment. However, the situation in the stomach is rather complex, consisting of two types of gastric units which show bidirectional self-renewal from an unexpectedly large variety of progenitor/stem cell populations. As in many other tumors, cancer stem cells have also been characterized for gastric cancer. This review focuses on the various gastric epithelial stem cells, how they contribute to self-renewal and which routes are known to gastric adenocarcinomas, including their stem cells.</description><subject>Adenocarcinoma - microbiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Animals</subject><subject>Bacteria</subject><subject>cancer stem cell</subject><subject>cell differentiation</subject><subject>Gastric cancer</subject><subject>gastric mucosa</subject><subject>Gastric Mucosa - microbiology</subject><subject>Gastric Mucosa - pathology</subject><subject>gastric self-renewal</subject><subject>gastric stem cell</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Infections</subject><subject>metaplasia</subject><subject>Neoplastic Stem Cells - microbiology</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Review</subject><subject>SPEM</subject><subject>Stem cells</subject><subject>Stomach - microbiology</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqFkktr3TAQhUVpaV5ddlsM3XTjVg_r4U0gNXlBoIs2azGWxokutnUr2YX--yq9ScjtpiDQjObjMDM6hLxn9LMQLf0SNlNmihrWMilekUPWcF5TqvTrF_EBOcp5QykXXLZvyQFX3Gim-SH52q0p4bxU3xdY1lzFuUQ4VR2OY65g9lUHs8NUKkO13GN1CXlJwVXn21DSMazTCXkzwJjx3eN9TG4vzn90V_XNt8vr7uymdtLQpXY9d1x71pteN5Q64yhy6cAjDkJKbLXizJcpJPMA6HvqlBfUONTOD4KJY3K90_URNnabwgTpt40Q7N-HmO4spCW4Ea1QgnLfeqUkawavgIm-8UMj0IMDqYvW6U5ru_YTelc2kGDcE92vzOHe3sVftpGG8fahmU-PAin-XDEvdgrZlaXBjHHNlhmhRTmM_x_VVGpuWiMK-vEfdBPXNJetFqrlhpdvU4Wqd5RLMeeEw3PfjNoHU9g9UxT-w8thn-knF4g_AjKyIA</recordid><startdate>20150814</startdate><enddate>20150814</enddate><creator>Hoffmann, Werner</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150814</creationdate><title>Current Status on Stem Cells and Cancers of the Gastric Epithelium</title><author>Hoffmann, Werner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-cb2c27d1b8b7400c8c0e25cadeef355e97621d91551daaedb0c6d308ce7cdf313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - microbiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Animals</topic><topic>Bacteria</topic><topic>cancer stem cell</topic><topic>cell differentiation</topic><topic>Gastric cancer</topic><topic>gastric mucosa</topic><topic>Gastric Mucosa - microbiology</topic><topic>Gastric Mucosa - pathology</topic><topic>gastric self-renewal</topic><topic>gastric stem cell</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Infections</topic><topic>metaplasia</topic><topic>Neoplastic Stem Cells - microbiology</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Review</topic><topic>SPEM</topic><topic>Stem cells</topic><topic>Stomach - microbiology</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - microbiology</topic><topic>Stomach Neoplasms - 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| subjects | Adenocarcinoma - microbiology Adenocarcinoma - pathology Animals Bacteria cancer stem cell cell differentiation Gastric cancer gastric mucosa Gastric Mucosa - microbiology Gastric Mucosa - pathology gastric self-renewal gastric stem cell Helicobacter Infections - complications Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Helicobacter pylori - isolation & purification Humans Infections metaplasia Neoplastic Stem Cells - microbiology Neoplastic Stem Cells - pathology Review SPEM Stem cells Stomach - microbiology Stomach - pathology Stomach Neoplasms - microbiology Stomach Neoplasms - pathology |
| title | Current Status on Stem Cells and Cancers of the Gastric Epithelium |
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